Drug interactions between lithium and Thorazine
Results for the following 2 drugs: |
|
|---|---|
| lithium | |
| Thorazine (chlorpromazine) | |
Interactions between your selected drugs
lithium ↔ chlorpromazine
Applies to:lithium and Thorazine (chlorpromazine)
MONITOR: Lithium and chlorpromazine have been used together in the setting of acute mania. However, concurrent administration of these drugs may induce a number of neurologic and psychiatric effects, even though phenothiazine levels may be decreased during lithium therapy. Mental status changes, extrapyramidal effects, fever, and other symptoms have been reported. The mechanism is unknown. One case has been reported in which severe hypotension was also associated with this combination.
MANAGEMENT: Patients should be closely monitored for toxic effects (e.g., excessive sedation, extrapyramidal effects). It may be necessary to discontinue one or both agents if an interaction is suspected.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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