liothyronine and Anisindione Interactions

Interactions between liothyronine and Anisindione (anisindione)

anisindione and liothyronine (Moderate Drug-Drug)

MONITOR: Thyroid hormones increase the catabolism of the clotting factors dependent on vitamin K. The hypoprothrombinemic response to oral anticoagulants may be enhanced. No significant effects are expected when warfarin is added to a patient stabilized on thyroid replacement.

MANAGEMENT: INR or prothrombin time should be monitored closely when adding, discontinuing, or changing thyroid hormone dosage. Patients should be advised to notify their physician if they experience any signs of excessive anticoagulation, such as unusual or prolonged bleeding, bruising, vomiting, change in stool or urine color, headache, dizziness, or weakness.