Drug interactions between Lexapro and metoprolol
Results for the following 2 drugs: |
|
|---|---|
| Lexapro (escitalopram) | |
| metoprolol | |
Interactions between your selected drugs
metoprolol ⇔ escitalopram
Applies to: metoprolol and Lexapro (escitalopram)
Escitalopram may increase the plasma concentrations of metoprolol. Administration of 20 mg/day escitalopram for 21 days resulted in a 50% increase of the maximum plasma concentration and an 82% increase of the AUC of metoprolol (single 100 mg dose); however, no clinically significant effects on blood pressure or heart rate occurred. The mechanism may be related to inhibition of CYP450 2D6 metabolism. Increased levels may decrease beta blocker cardioselectivity. It may be advisable to monitor patients for increased pharmacological effects of metoprolol.
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