lescol and E mycin Interactions

Interactions between lescol(fluvastatin) and E mycin (erythromycin)

erythromycin and fluvastatin (Major Drug-Drug)

GENERALLY AVOID: Severe myopathy and rhabdomyolysis have been reported with concomitant use of HMG-CoA reductase inhibitors and erythromycin in severely ill patients. The suspected mechanism is inhibition of HMG-CoA reductase inhibitor metabolism by CYP450 3A4 isoenzymes.

MANAGEMENT: While these effects have not been reported with concomitant use of fluvastatin and erythromycin, alternative therapy should be considered. If patients do receive this combination, they should be instructed to report symptoms of muscular pain, weakness, tenderness, malaise, or fever. If such symptoms occur, creatine kinase should be measured. Fluvastatin and erythromycin should be discontinued if creatine kinase is elevated.