Drug interactions between Lasix and Tekturna
| Results for the following 2 drugs: |
|---|
| Lasix (furosemide) |
| Tekturna (aliskiren) |
Interactions between your selected drugs
furosemide ↔ aliskiren
Applies to:Lasix (furosemide) and Tekturna (aliskiren)
MONITOR: Coadministration with aliskiren may decrease the blood concentrations of furosemide. The mechanism of interaction has not been described. According to the product labeling for aliskiren, peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of furosemide were reduced by approximately 50% and 30%, respectively, during concomitant administration. Furosemide had no significant effect on the systemic exposure of aliskiren.
MANAGEMENT: The potential for diminished pharmacologic effects of furosemide should be considered during coadministration with aliskiren.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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