Drug interactions between Lasix and Metaglip
| Results for the following 2 drugs: |
|---|
| Lasix (furosemide) |
| Metaglip (glipizide/metformin) |
Interactions between your selected drugs
furosemide ↔ glipizide
Applies to:Lasix (furosemide) and Metaglip (glipizide/metformin)
MONITOR: The efficacy of oral hypoglycemic agents and insulin may be diminished by certain drugs, including thiazides and other diuretics, corticosteroids, estrogens, progestins, thyroid hormones, human growth hormone, gonadotropin-releasing hormone agonists, phenothiazines, atypical antipsychotics, sympathomimetic amines, protease inhibitors, phenytoin, megestrol, danazol, isoniazid, asparaginase, pegaspargase, diazoxide, temsirolimus, sucralfate oral suspension, as well as pharmacologic dosages of nicotinic acid and adrenocorticotropic agents. These drugs may interfere with blood glucose control because they can cause hyperglycemia, glucose intolerance, new-onset diabetes mellitus, and/or exacerbation of preexisting diabetes.
MANAGEMENT: Close clinical monitoring of glycemic control is recommended if these drugs are coadministered with antidiabetic agents. Likewise, patients should be observed for hypoglycemia when these drugs are withdrawn from their therapeutic regimen. Dose adjustments of the hypoglycemic agent may be required.
furosemide ↔ metformin
Applies to:Lasix (furosemide) and Metaglip (glipizide/metformin)
MONITOR: One study has suggested that furosemide may increase plasma concentrations of metformin by 22% (without changes in metformin clearance) and that metformin may decrease the peak concentration and elimination half-life of furosemide by 31% and 32%, respectively. The clinical implications of these findings are uncertain. Increased metformin levels may increase the risk of lactic acidosis.
MANAGEMENT: If furosemide and metformin must be used together, it is recommended that the clinician observe closely for evidence that the effects of either drug have been altered. Patients should be advised to monitor their blood glucose and to promptly notify their physician if they experience possible signs of lactic acidosis such as malaise, myalgia, respiratory distress, hyperventilation, slow or irregular heartbeat, somnolence, abdominal upset, or other unusual symptoms.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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