lapatinib and Mellaril s Interactions

Interactions between lapatinib and Mellaril s (thioridazine)

thioridazine and lapatinib (Major Drug-Drug)

CONTRAINDICATED: Thioridazine can cause dose-related prolongation of the QT interval. Theoretically, coadministration with other agents that can prolong the QT interval may result in elevated risk of ventricular arrhythmias, including ventricular tachycardia and torsade de pointes, because of additive arrhythmogenic potential related to their effects on cardiac conduction. Thioridazine treatment alone has been associated with several reported cases of torsade de pointes and sudden death.

MANAGEMENT: The concurrent use of thioridazine with other medications that can prolong the QT interval is considered contraindicated.