Drug interactions between Lanoxin and Noxafil
| Results for the following 2 drugs: |
|---|
| Lanoxin (digoxin) |
| Noxafil (posaconazole) |
Interactions between your selected drugs
digoxin ↔ posaconazole
Applies to:Lanoxin (digoxin) and Noxafil (posaconazole)
MONITOR: Theoretically, posaconazole may increase the plasma concentrations and pharmacologic effects of digoxin. Although clinical data are lacking, the interaction has been reported with other azole antifungal agents. Two- to fourfold increases in digoxin concentrations have been reported after initiation of itraconazole. Toxicity has occurred in some cases, most with an onset of 9 to 13 days following the start of azole therapy. The exact mechanism of the interaction is unknown but may be related to azole-induced inhibition of the P-glycoprotein transport of digoxin, resulting in reduced renal clearance.
MANAGEMENT: Caution is advised if digoxin must be used concurrently with posaconazole. Serum digoxin levels should be checked frequently and the dosage adjusted accordingly, particularly following initiation or discontinuation of posaconazole in patients who are stabilized on their digoxin regimen. Patients should be advised to notify their doctor if they experience signs of digoxin toxicity such as nausea, anorexia, visual disturbances, slow pulse, or irregular heartbeats.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. Multum's drug information does not endorse drugs, diagnose patients, or recommend therapy. Multum's drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2012 Multum Information Services, Inc. The information in contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.
