lanoxicaps and Adriamycin Interactions

Interactions between lanoxicaps(digoxin) and Adriamycin (DOXOrubicin)

digoxin and DOXOrubicin (Moderate Drug-Drug)

MONITOR: Some antineoplastic agents have been associated with decreased gastrointestinal absorption of digoxin. The suspected mechanism is alteration of the gastrointestinal mucosa. The risk of an interaction is expected to be less with digoxin solution in capsules because absorption occurs rapidly in the upper GI tract.

MANAGEMENT: During coadministration, the patient should be monitored for digoxin effectiveness. Serum digoxin levels should be monitored and the digoxin dosage adjusted as necessary. Also, the clinician should be aware that the risk of digoxin toxicity is increased when an antineoplastic agent is discontinued or interrupted for longer than a few days.