Drug interactions between lamivudine and trimethoprim
Results for the following 2 drugs: |
|
|---|---|
| lamivudine | |
| trimethoprim | |
Interactions between your selected drugs
trimethoprim ⇔ lamivudine
Applies to: trimethoprim and lamivudine
In a study with 14 HIV-positive patients, coadministration of trimethoprim/sulfamethoxazole (TMP/SMX DS once a day for 5 days) and lamivudine (300 mg single dose on day 5) resulted in a mean decrease of 35% in lamivudine renal clearance and a mean increase of 43% in lamivudine area under the plasma concentration-time curve. The mechanism of interaction is thought to be competitive inhibition of tubular secretion by trimethoprim. Lamivudine did not affect the pharmacokinetic profile of TMP/SMX. Given the favorable safety profile of lamivudine, this interaction is unlikely to be of clinical significance. However, the effect of higher dosages of TMP/SMX on lamivudine pharmacokinetics has not been investigated.
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