Drug interactions between Lamictal and olanzapine
| Results for the following 2 drugs: |
|---|
| Lamictal (lamotrigine) |
| olanzapine |
Interactions between your selected drugs
lamotrigine ↔ olanzapine
Applies to:Lamictal (lamotrigine) and olanzapine
Coadministration with olanzapine may slightly decrease the plasma concentrations of lamotrigine. The mechanism of interaction has not been described. In 16 healthy male volunteers, addition of olanzapine (15 mg once daily) decreased the peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of lamotrigine (200 mg once daily) by 20% and 24%, respectively, compared to administration of lamotrigine alone in 12 healthy male volunteers. These alterations are unlikely to be of clinical significance. In another study, olanzapine 5 mg had no effect on the Cmax and AUC of lamotrigine (25 mg daily for 5 days, then 50 mg daily for 13 days) in 14 healthy volunteers, but significantly increased the mean time to reach peak plasma concentration (Tmax) of lamotrigine from 1.9 to 4.0 hours. This effect may be attributable to the anticholinergic properties of olanzapine. Mild sedation was the only adverse effect reported during lamotrigine and olanzapine coadministration. Lamotrigine has no effect on the pharmacokinetics of olanzapine.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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