lactulose and Camptosar Interactions

Interactions between lactulose and Camptosar (irinotecan)

lactulose and irinotecan (Moderate Drug-Drug)

GENERALLY AVOID: Because irinotecan has been reported to cause diarrhea in the majority of treated patients, use of laxatives is not recommended during irinotecan administration.

MANAGEMENT: For patients requiring laxatives for constipation associated with narcotic administration, the standard regimen may be continued under supervision of the clinician. However, the patient must be educated to contact the clinician with any change in bowel habits so that adjustments or discontinuation of laxative doses may be made promptly.