labetalol-hydrochloride and Aldomet Interactions

Interactions between labetalol-hydrochloride(labetalol) and Aldomet (methyldopa)

labetalol and methyldopa (Major Drug-Drug)

GENERALLY AVOID: The combination of nonselective beta-blockers and methyldopa may cause hypertensive crises. Death has been reported. Causality has not been clearly established, as other drugs were involved. The mechanism may be related to unopposed alpha effects. Phentolamine may be useful for treatment of this interaction.

MANAGEMENT: It may be best to avoid this combination. Patients' blood pressure should be monitored during concurrent therapy. Patients should be advised to seek medical help if they experience any early symptoms of a hypertensive crisis including nausea, vomiting, sweating, flushing, stiff neck, headache, or palpitations.