kuvan and Levodopa Interactions

Interactions between kuvan(sapropterin) and Levodopa (levodopa)

levodopa and sapropterin (Moderate Drug-Drug)

MONITOR: Coadministration of sapropterin and levodopa has been associated with neurologic adverse effects. The mechanism of interaction has not been described. In a 10-year postmarketing safety surveillance program for a non-PKU indication using a particular formulation of sapropterin, three patients with underlying neurologic disorders experienced convulsions, exacerbation of convulsions, overstimulation, and irritability during coadministration with levodopa.

MANAGEMENT: Caution is advised if sapropterin is prescribed to patients receiving levodopa.