Drug interactions between Ketek and trazodone
Results for the following 2 drugs: |
|
|---|---|
| Ketek (telithromycin) | |
| trazodone | |
Interactions between your selected drugs
trazodone ⇔ telithromycin
Applies to: trazodone and Ketek (telithromycin)
ADJUST DOSE: Coadministration with potent CYP450 3A4 inhibitors such as clarithromycin, erythromycin, itraconazole, ketoconazole, and protease inhibitors may increase the plasma concentrations and pharmacologic effects of trazodone, which is primarily metabolized by the isoenzyme. In ten healthy volunteers, ritonavir (200 mg orally for 4 doses) increased the mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of trazodone (50 mg single dose) by 34% and 137%, respectively, compared to placebo. Trazodone elimination half-life was prolonged 122% with ritonavir, while apparent oral clearance decreased 52%. Sedation, fatigue, and performance impairment were also increased during coadministration with ritonavir, and three subjects experienced nausea, dizziness, and hypotension.
MANAGEMENT: A lower dosage of trazodone should be considered during coadministration with a potent CYP450 3A4 inhibitor if concomitant use cannot be avoided. Pharmacologic response to trazodone should be monitored more closely whenever a CYP450 3A4 inhibitor is added to or withdrawn from therapy, and the trazodone dosage adjusted as necessary.
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