Drug interactions between Ketek and Metoprolol Succinate ER
| Results for the following 2 drugs: |
|---|
| Ketek (telithromycin) |
| Metoprolol Succinate ER (metoprolol) |
Interactions between your selected drugs
metoprolol ↔ telithromycin
Applies to:Metoprolol Succinate ER (metoprolol) and Ketek (telithromycin)
MONITOR: Coadministration with telithromycin may increase the plasma concentrations of metoprolol. The proposed mechanism is telithromycin inhibition of CYP450 2D6, the isoenzyme responsible for the metabolic clearance of metoprolol. Coadministration of telithromycin and metoprolol has resulted in an increase of approximately 38% in the peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of metoprolol, with no change in the elimination half-life. Single-dose metoprolol had no significant effect on the AUC of telithromycin.
MANAGEMENT: In patients treated with metoprolol for heart failure, the increased exposure to metoprolol may be of clinical importance, thus coadministration with telithromycin should be considered with caution. Excessive beta blockade may worsen heart failure in patients who have dependency to sympathetic stimulation in maintaining hemodynamic function.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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