kava and Clolar Interactions

Interactions between kava and Clolar (clofarabine)

kava and clofarabine (Moderate Drug-Drug)

GENERALLY AVOID: Since the liver is a known target organ for clofarabine toxicity (i.e., hepatomegaly, jaundice), concomitant use of agents known to induce hepatotoxicity may potentiate the risk of liver injury.

MANAGEMENT: The use of clofarabine with other agents that are potentially hepatotoxic (e.g., alcohol; androgens and anabolic steroids; antituberculous agents; azole antifungal agents; ACE inhibitors; endothelin receptor antagonists; interferons; nucleoside reverse transcriptase inhibitors; thiazolidinediones; anticonvulsants such as carbamazepine, hydantoins, felbamate, and valproic acid; lipid-lowering medications such as fenofibrate, HMG-CoA reductase inhibitors, and niacin; herbal products such as kava and echinacea) should be avoided if possible. Patients treated with clofarabine should be advised to seek medical attention if they experience potential signs and symptoms of hepatotoxicity such as fever, rash, anorexia, nausea, vomiting, fatigue, right upper quadrant pain, dark urine, and jaundice.