kava and Alprazolam extended release Interactions

Interactions between kava and Alprazolam extended release (alprazolam)

alprazolam and kava (Moderate Drug-Drug)

GENERALLY AVOID: A case report suggests that kava may increase the central nervous system adverse effects of benzodiazepines. In the report, a 54-year-old man treated with alprazolam became semicomatose with lethargy and disorientation following self-medication with kava for 3 days. The exact mechanism of interaction is unknown, but an additive or synergistic CNS effect is suspected.

MANAGEMENT: Until further information is available, concomitant use of kava and benzodiazepines is not recommended. Patients on benzodiazepines should be advised to consult their caregiver before using any alternative medicines.