kanamycin and Coly mycin m Interactions

Interactions between kanamycin and Coly mycin m (colistimethate)

kanamycin and colistimethate (Major Drug-Drug)

GENERALLY AVOID: The combination of a polypeptide antibiotic and an aminoglycoside increases the risk of respiratory paralysis and renal dysfunction. The mechanism of this interaction is not known.

MANAGEMENT: This combination should be avoided concurrently or sequentially.