ka-pec and Cleocin hcl Interactions

Interactions between ka-pec(attapulgite) and Cleocin hcl (clindamycin)

clindamycin and attapulgite (Moderate Drug-Drug)

GENERALLY AVOID: Absorbent antidiarrheal agents may significantly reduce the gastrointestinal absorption of oral clindamycin and lincomycin, causing decreased serum levels and potential loss of antimicrobial effectiveness. Kaolin-pectin has been associated with a 90% reduction in lincomycin levels.

MANAGEMENT: The use of absorbent antidiarrheals should be avoided if possible. If used concurrently, the patient should be monitored closely for loss of antibiotic efficacy.