k-pek and Astramorph pf Interactions

Interactions between k-pek(bismuth subsalicylate) and Astramorph pf (morphine)

morphine and bismuth subsalicylate (Moderate Drug-Drug)

MONITOR: Coadministration of narcotic analgesics with antidiarrheal agents may have additive central nervous system (CNS) and gastrointestinal (GI) system effects, and increase the risk of severe constipation or paralytic ileus and CNS depression.

MANAGEMENT: If concomitant use cannot be avoided, patients should be monitored for potentially excessive or prolonged CNS depression and constipation. Ambulatory patients should be counseled to avoid activities requiring mental alertness until they know how these agents affect them.