k-pek and Apresoline Interactions

Interactions between k-pek(bismuth subsalicylate) and Apresoline (hydrALAZINE)

hydrALAZINE and bismuth subsalicylate (Moderate Drug-Drug)

MONITOR: Nonsteroidal anti-inflammatory drugs (NSAIDs) may attenuate the antihypertensive effect of hydralazine and dihydralazine. This interaction suggests that prostaglandins play a pivotal role in the vasodilatory effects of hydralazine. However, data have been conflicting.

MANAGEMENT: Recommended management consists of monitoring the antihypertensive effectiveness of hydralazine or dihydralazine during therapy, increasing the dosage as necessary, or decreasing or substituting another drug for the NSAID.