Drug interactions between Janumet and Tolinase
| Results for the following 2 drugs: |
|---|
| Janumet (metformin/sitagliptin) |
| Tolinase (tolazamide) |
Interactions between your selected drugs
tolazamide ↔ sitagliptin
Applies to:Tolinase (tolazamide) and Janumet (metformin/sitagliptin)
ADJUST DOSE: Coadministration of a dipeptidyl peptidase-4 inhibitor with an insulin secretagogue (e.g., sulfonylurea, meglitinide) or insulin may potentiate the risk of hypoglycemia.
MANAGEMENT: A lower dosage of the insulin secretagogue or insulin may be required when used in combination with a dipeptidyl peptidase-4 inhibitor.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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