Drug interactions between Jantoven and tamoxifen
Results for the following 2 drugs: |
|
|---|---|
| Jantoven (warfarin) | |
| tamoxifen | |
Interactions between your selected drugs
warfarin ⇔ tamoxifen
Applies to: Jantoven (warfarin) and tamoxifen
CONTRAINDICATED: Tamoxifen may enhance the hypoprothrombinemic response to warfarin. Response to other anticoagulants may be affected as well. The mechanism is unknown but may be due to competition for the same metabolic pathways. Severe and/or fatal hemorrhages have been reported with concomitant use of coumarin derivatives. A similar interaction may occur with toremifene and other triphenylethylene antiestrogens. MANAGEMENT: When used to reduce the incidence of breast cancer in high-risk women, tamoxifen is considered contraindicated in patients requiring concomitant coumarin anticoagulants. Other patients should be closely monitored for excessive anticoagulation and prolonged prothrombin times. Patients should be advised to notify their physicians if they experience any signs of excessive anticoagulation, such as unusual or prolonged bleeding, bruising, vomiting, change in stool or urine color, headache, dizziness, or weakness.
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