Drug interactions between itraconazole and Neoral
| Results for the following 2 drugs: |
|---|
| itraconazole |
| Neoral (cyclosporine) |
Interactions between your selected drugs
cyclosporine ↔ itraconazole
Applies to:Neoral (cyclosporine) and itraconazole
ADJUST DOSE: Certain azole antifungal agents such as ketoconazole and itraconazole that are potent inhibitors of CYP450 3A4 may significantly increase the blood levels of cyclosporine, which is primarily metabolized by the isoenzyme. The risk of nephro- and neurotoxicity associated with cyclosporine may be increased. Five- to tenfold increases in cyclosporine levels have been reported during coadministration with ketoconazole.
MANAGEMENT: Cyclosporine dosage reductions are often necessary during coadministration with azole antifungal agents. Cyclosporine blood levels and renal function should be checked frequently and the dosage adjusted accordingly, particularly following initiation or discontinuation of antifungal therapy in patients who are stabilized on their cyclosporine regimen. A 60% to 80% reduction may be necessary during concomitant therapy with ketoconazole. Patients should be advised to notify their doctor if they experience possible signs of cyclosporine toxicity such as nausea, vomiting, diarrhea, abdominal pain, dizziness, fatigue, headache, tremors, and convulsions.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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