isoniazid and Halothane Interactions

Interactions between isoniazid and Halothane (halothane)

isoniazid and halothane (Major Drug-Drug)

GENERALLY AVOID: The hepatotoxic effects of rifampin and isoniazid appear to be increased when these drugs are administered together after halothane anesthesia. Cases of hepatotoxicity and hepatic encephalopathy, one of which was fatal, have been reported. A similar reaction may occur with rifabutin. The mechanism and causality have not been definitely determined since rifampin, isoniazid or halothane alone are potentially hepatotoxic.

MANAGEMENT: Until more information is available, it is best to avoid this combination after halothane anesthesia.