Drug interactions between isoniazid and Sandimmune
Results for the following 2 drugs: |
|
|---|---|
| isoniazid | |
| Sandimmune (cyclosporine) | |
Interactions between your selected drugs
cyclosporine ⇔ isoniazid
Applies to: Sandimmune (cyclosporine) and isoniazid
MONITOR: Isoniazid may decrease serum cyclosporine concentrations. The mechanism is induction of hepatic CYP450 3A4 metabolism by isoniazid. Although cyclosporine and isoniazid have been safely used together in clinical trials with renal and heart transplant patients, individual cases of reduced cyclosporine blood levels have been reported.
MANAGEMENT: If these agents are used concomitantly, cyclosporine levels should be closely monitored. If an interaction is suspected, alterations in cyclosporine dosage may be necessary.
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