Drug interactions between Isentress and Sustiva
| Results for the following 2 drugs: |
|---|
| Isentress (raltegravir) |
| Sustiva (efavirenz) |
Interactions between your selected drugs
efavirenz ↔ raltegravir
Applies to:Sustiva (efavirenz) and Isentress (raltegravir)
Coadministration with efavirenz may reduce the plasma concentrations of raltegravir. The mechanism of interaction has not been described. In 9 study subjects administered a single 400 mg dose of raltegravir in combination with efavirenz 600 mg daily, raltegravir peak plasma concentration (Cmax), systemic exposure (AUC) and trough plasma concentration (Cmin) decreased by 36%, 36% and 21%, respectively, compared to administration of raltegravir alone. These changes were statistically, but not clinically, significant. Raltegravir and efavirenz may be coadministered without any dosage adjustments.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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