Drug interactions between Isentress and Reyataz
| Results for the following 2 drugs: |
|---|
| Isentress (raltegravir) |
| Reyataz (atazanavir) |
Interactions between your selected drugs
atazanavir ↔ raltegravir
Applies to:Reyataz (atazanavir) and Isentress (raltegravir)
Coadministration with inhibitors of uridine diphosphate glucuronosyltransferase (UGT) 1A1 such as atazanavir, nilotinib, or sorafenib may increase the plasma concentrations of raltegravir, which is primarily metabolized by UGT1A1-mediated glucuronidation. However, concurrent use of atazanavir/ritonavir in clinical trials did not result in meaningful differences in the safety of raltegravir. Based on these data, no dosage adjustment of raltegravir is necessary when used together with atazanavir/ritonavir or other UGT1A1 inhibitors.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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