ipratropium and Adgan Interactions

Interactions between ipratropium and Adgan (promethazine)

ipratropium and promethazine (Minor Drug-Drug)

Theoretically, the potential exists for additive anticholinergic effects such as mydriasis, blurred vision, heat intolerance, fever, dry mouth, tachycardia, urinary retention, and constipation when ipratropium, oxitropium or tiotropium is used with each other or other agents with anticholinergic properties (e.g., antihistamines, antispasmodics, neuroleptics, phenothiazines, skeletal muscle relaxants, tricyclic antidepressants, class IA antiarrhythmics especially disopyramide). However, due to the poor systemic absorption of ipratropium, oxitropium, and tiotropium when administered locally, the interaction would be unlikely at regularly recommended dosages.