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Drug Interactions between interferon alfacon-1 and Promacta

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

interferon alfacon-1 eltrombopag

Applies to: interferon alfacon-1 and Promacta (eltrombopag)

For patients with chronic hepatitis C, using eltrombopag together with interferon alfacon-1 may worsen liver function and increase liver problems. The risk is greatest in patients who already have advanced liver disease or cirrhosis. Liver failure may occur, resulting in complications like ascites (accumulation of fluid in the abdominal cavity), hepatic encephalopathy (confusion, altered consciousness, or coma due to accumulation of toxic substances in the bloodstream), variceal hemorrhage (bleeding in the esophagus or stomach due to dilated veins), and bacterial peritonitis (infection of the inner abdominal wall lining). Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and is monitoring you closely for any potential complications. You should seek immediate medical attention if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

eltrombopag food

Applies to: Promacta (eltrombopag)

Food may reduce the absorption and blood levels of eltrombopag. In addition, minerals such as aluminum, calcium, iron, magnesium, and zinc can also interfere with eltrombopag absorption into the bloodstream, which may make the medication less effective in treating your condition. You should take eltrombopag on an empty stomach one hour before or two hours after a meal. Eltrombopag should also be taken at least 2 hours before or 4 hours after products like antacids, mineral supplements, dairy products, and fortified juices. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.