Drug interactions between Intelence and Norvir
| Results for the following 2 drugs: |
|---|
| Intelence (etravirine) |
| Norvir (ritonavir) |
Interactions between your selected drugs
ritonavir ↔ etravirine
Applies to:Norvir (ritonavir) and Intelence (etravirine)
GENERALLY AVOID: Coadministration with full-dose ritonavir (600 mg twice a day) may significantly decrease the plasma concentrations of etravirine. The mechanism of interaction has not been described but may involve ritonavir induction of CYP450 2C19 and 2C9, of which etravirine is a substrate. In 11 study subjects administered etravirine with ritonavir 600 mg twice a day, etravirine peak plasma concentration (Cmax) decreased by 32% and systemic exposure (AUC) decreased by 46%.
MANAGEMENT: Given the risk of reduced viral susceptibility and resistance development associated with subtherapeutic antiretroviral drug levels, the use of etravirine in combination with full-dose ritonavir should be avoided. Etravirine may be used with low-dose ritonavir administered as a pharmacokinetic booster in certain protease inhibitor regimens.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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