integrilin and Agrylin Interactions

Interactions between integrilin(eptifibatide) and Agrylin (anagrelide)

anagrelide and eptifibatide (Major Drug-Drug)

MONITOR CLOSELY: The combination of glycoprotein IIb/IIIa inhibitors and anagrelide can theoretically significantly increase the risk of bleeding. GP IIb/IIIa inhibitors inhibit platelet aggregation by blocking the fibrinogen, von Willebrand factor, and other adhesive ligands to platelets. The mechanism whereby anagrelide decreases platelet concentrations is not known. The combination of these drugs, therefore, could decrease platelet number and function.

MANAGEMENT: Extraordinary precautions are recommended if these drugs must be used together, including monitoring platelet counts and hemoglobin concentrations. In addition, invasive procedures, such as urinary catheterization, nasogastric or nasotracheal intubation, and even venous punctures should be avoided or minimized. Non-compressible venous access sites, such as jugular or subclavian sites, should be avoided.