Drug interactions between indinavir and Xanax
Results for the following 2 drugs: |
|
|---|---|
| indinavir | |
| Xanax (alprazolam) | |
Interactions between your selected drugs
alprazolam ⇔ indinavir
Applies to: Xanax (alprazolam) and indinavir
CONTRAINDICATED: Coadministration with indinavir may significantly increase the plasma concentrations and pharmacologic effects of alprazolam. The proposed mechanism is indinavir inhibition of intestinal and hepatic CYP450 3A4, the isoenzyme responsible for the first-pass and hepatic metabolism of alprazolam. MANAGEMENT: Given the potential for prolonged and/or increased sedation and respiratory depression associated with excessive benzodiazepine blood levels, concomitant use of indinavir with alprazolam is considered contraindicated.
See also...
Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. Multum's drug information does not endorse drugs, diagnose patients, or recommend therapy. Multum's drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2009 Multum Information Services, Inc. The information in contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.
