Drug interactions between indinavir and Synthroid
Results for the following 2 drugs: |
|
|---|---|
| indinavir | |
| Synthroid (levothyroxine) | |
Interactions between your selected drugs
levothyroxine ⇔ indinavir
Applies to:Synthroid (levothyroxine) and indinavir
MONITOR: A single case report suggests that indinavir may increase serum thyroxine concentrations, potentially resulting in hyperthyroidism. The proposed mechanism is indinavir inhibition of glucuronosyltransferase, which is partially responsible for the metabolic clearance of thyroxine. The case report describes an HIV-infected patient who had been stabilized on levothyroxine 0.75 mg/day for several years when treatment with stavudine, lamivudine, and indinavir was begun. Approximately 50 days later, she presented with nervousness, palpitations, restlessness, weakness, and slight weight loss. Thyroid function testing revealed suppression of thyroid-stimulating hormone (TSH less than 0.1 mIU/L), increased free T4 (57 pmol/L), and increased free T3 (33 pmol/L). Thyroid function returned to normal one month after the levothyroxine dose was reduced to 0.12 mg/day.
MANAGEMENT: During coadministration with indinavir, the possibility of an enhanced therapeutic response to levothyroxine should be considered. Dosage adjustment as well as clinical and laboratory monitoring may be appropriate whenever indinavir is added to or withdrawn from therapy.
See also...
Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. Multum's drug information does not endorse drugs, diagnose patients, or recommend therapy. Multum's drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2010 Multum Information Services, Inc. The information in contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.
