Drug interactions between Inderide and Somatuline Depot
| Results for the following 2 drugs: |
|---|
| Inderide (hydrochlorothiazide/propranolol) |
| Somatuline Depot (lanreotide) |
Interactions between your selected drugs
propranolol ↔ lanreotide
Applies to:Inderide (hydrochlorothiazide/propranolol) and Somatuline Depot (lanreotide)
MONITOR: Somatostatin analogs (e.g., octreotide, lanreotide) can decrease heart rate and may potentiate the bradycardic effects of drugs like beta-blockers, calcium channel blockers, digitalis glycosides, and certain antiarrhythmic agents (e.g., class I antiarrhythmics, adenosine, amiodarone). Octreotide has commonly been associated with bradycardia (less than 50 bpm), conduction abnormalities, and arrhythmias in acromegalic patients. Occasional cases of sinus bradycardia and ventricular tachycardia have also been reported with lanreotide.
MANAGEMENT: Caution is advised if somatostatin analogs are prescribed with agents that exhibit bradycardic effects, including ophthalmic formulations of beta-blockers. Heart rate and blood pressure should be monitored.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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