Drug interactions between Inderide and rifampin
| Results for the following 2 drugs: |
|---|
| Inderide (hydrochlorothiazide/propranolol) |
| rifampin |
Interactions between your selected drugs
propranolol ↔ rifampin
Applies to:Inderide (hydrochlorothiazide/propranolol) and rifampin
MONITOR: Rifampin may decrease serum levels and effects of some oral beta-blockers. The proposed mechanism is increased CYP450 oxidative metabolism of beta-blockers that are hepatically metabolized. Renally excreted beta-blockers such as atenolol, carteolol, nadolol, or sotalol are not expected to interact.
MANAGEMENT: Patients should be monitored for clinical response and tolerance when rifampin is added to or discontinued from a beta-blocker regimen. The beta-blocker dosage may require adjustment.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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