Drug interactions between Inderide and Niferex-150
| Results for the following 2 drugs: |
|---|
| Inderide (hydrochlorothiazide/propranolol) |
| Niferex-150 (ascorbic acid/iron polysaccharide) |
Interactions between your selected drugs
propranolol ↔ ascorbic acid
Applies to:Inderide (hydrochlorothiazide/propranolol) and Niferex-150 (ascorbic acid/iron polysaccharide)
Limited data suggest that ascorbic acid may decrease the oral bioavailability of propranolol by possibly interfering with its absorption from the gastrointestinal tract. In 5 healthy subjects, pretreatment with a 2 gram dose of ascorbic acid 30 minutes before an 80 mg dose of propranolol decreased the peak plasma concentration (Cmax) and 24-hour area under the concentration-time curve (AUC) of propranolol by 28% and 37%, respectively, compared to when propranolol was administered alone. The time to reach maximum propranolol concentration (Tmax) was increased from 1.9 to 2.7 hours, and the total amount of drug (including metabolites) recovered in urine was significantly diminished. Although the heart rate decreased less during coadministration with ascorbic acid, the clinical significance is considered minor.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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