Drug interactions between Inderide and nefazodone
| Results for the following 2 drugs: |
|---|
| Inderide (hydrochlorothiazide/propranolol) |
| nefazodone |
Interactions between your selected drugs
propranolol ↔ nefazodone
Applies to:Inderide (hydrochlorothiazide/propranolol) and nefazodone
MONITOR: Nefazodone may potentiate the hypotensive effect of many drugs including vasodilators and antihypertensive agents. Orthostatic hypotension may occur. In clinical studies, nefazodone was associated with potentially significant blood pressure decreases (SBP 90 mmHg or less and at least 20 mmHg decrease from baseline) in 5.1% of patients, postural hypotension in 2.8%, and syncope in 0.2% (versus 0.3% for placebo).
MANAGEMENT: Caution and close monitoring for altered efficacy and safety are recommended if patients receive nefazodone with agents that can produce significant hypotension such as antihypertensive agents or vasodilators. Patients should be made aware of the possible side effects (e.g., dizziness, lightheadedness, orthostasis) and be cautioned about driving, operating machinery, or performing other hazardous tasks. They should also be advised to avoid rising abruptly from a sitting or recumbent position and to contact their physician if they experience symptoms of hypotension such as dizziness, lightheadedness, or fainting.
hydrochlorothiazide ↔ nefazodone
Applies to:Inderide (hydrochlorothiazide/propranolol) and nefazodone
MONITOR: Nefazodone may potentiate the hypotensive effect of many drugs including vasodilators and antihypertensive agents. Orthostatic hypotension may occur. In clinical studies, nefazodone was associated with potentially significant blood pressure decreases (SBP 90 mmHg or less and at least 20 mmHg decrease from baseline) in 5.1% of patients, postural hypotension in 2.8%, and syncope in 0.2% (versus 0.3% for placebo).
MANAGEMENT: Caution and close monitoring for altered efficacy and safety are recommended if patients receive nefazodone with agents that can produce significant hypotension such as antihypertensive agents or vasodilators. Patients should be made aware of the possible side effects (e.g., dizziness, lightheadedness, orthostasis) and be cautioned about driving, operating machinery, or performing other hazardous tasks. They should also be advised to avoid rising abruptly from a sitting or recumbent position and to contact their physician if they experience symptoms of hypotension such as dizziness, lightheadedness, or fainting.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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