ibutilide and Betapace af Interactions

Interactions between ibutilide and Betapace af (sotalol)

sotalol and ibutilide (Major Drug-Drug)

CONTRAINDICATED: Class III antiarrhythmic agents and ibutilide have additive effects and may prolong cardiac refractoriness.

MANAGEMENT: Class III antiarrhythmic agents should not be given concomitantly with ibutilide (which also has class III properties) or within four hours after ibutilide is given. In clinical trials, other class III antiarrhythmic agents were withheld for at least five half-lives prior to ibutilide infusion and for four hours after dosing, but thereafter were allowed at the physician's discretion.