Drug interactions between ibuprofen/oxycodone and Suboxone
| Results for the following 2 drugs: |
|---|
| ibuprofen/oxycodone |
| Suboxone (buprenorphine/naloxone) |
Interactions between your selected drugs
naloxone ↔ oxycodone
Applies to:Suboxone (buprenorphine/naloxone) and ibuprofen/oxycodone
MONITOR CLOSELY: This warning does not apply to the naloxone component in oral pentazocine/naloxone tablets. Naloxone injection is an antagonist that will reverse the actions of opiates. This reversal can occur when the opiate drug is being used clinically and when it is being abused. Physically dependent patients may experience withdrawal symptoms. Abrupt postoperative opioid reversal has resulted in hypotension, ventricular tachycardia and fibrillation, pulmonary edema, cardiac arrest, encephalopathy, and death.
MANAGEMENT: Patients receiving naloxone injection should be monitored for changes in vital signs, nausea, vomiting, diarrhea, aches, fever, runny nose, sneezing, nervousness, irritability, shivering, abdominal cramps.
oxycodone ↔ buprenorphine
Applies to:ibuprofen/oxycodone and Suboxone (buprenorphine/naloxone)
GENERALLY AVOID: Mixed agonist/antagonist analgesics may reduce the analgesic effect of pure opioid agonists and/or precipitate withdrawal symptoms in patients who have received or are receiving a course of therapy with a pure opioid agonist analgesic.
MANAGEMENT: Mixed agonist/antagonist analgesics such as pentazocine, nalbuphine, dezocine, butorphanol, and buprenorphine should generally be avoided or administered with caution to patients who have received or are receiving pure opioid agonists.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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