Drug interactions between Hypaque-M and ibutilide
| Results for the following 2 drugs: |
|---|
| Hypaque-M (diatrizoate) |
| ibutilide |
Interactions between your selected drugs
diatrizoate ↔ ibutilide
Applies to:Hypaque-M (diatrizoate) and ibutilide
MONITOR: The use of iodine-containing contrast media for coronary angiography in patients treated with certain antiarrhythmics such as amiodarone may result in significant prolongation of the QT interval. These contrast agents can be arrhythmogenic when injected into the coronary arteries and may have additive effects on cardiac repolarization when coadministered with antiarrhythmic agents that prolong the QT interval. In a retrospective study of patients who underwent cardiac catheterization at a German hospital, 21 patients who had been receiving long-term amiodarone therapy exhibited significantly increased QT interval 12 to 24 hours after catheterization compared to 21 age-matched controls who received cardiac catheterization without prior amiodarone or other QT prolonging treatment. In the amiodarone group, the QTc interval (i.e., QT interval corrected for heart rate) increased on average by 10% from 433 ms to 480 ms. QTc prolongation exceeding 500 ms did not occur in any of the amiodarone patients before catheterization but occurred in 6 patients after catheterization. No significant change was observed in the control group.
MANAGEMENT: Caution is advised if iodine-containing contrast media are used for coronary angiography in patients treated with class IA (e.g., disopyramide, quinidine, procainamide) or class III (e.g., amiodarone, dofetilide, ibutilide, sotalol) antiarrhythmic agents. Increased surveillance and ECG monitoring may be appropriate. Patients who receive outpatient angiographies should be advised to seek medical attention if they experience symptoms that could indicate the occurrence of arrhythmia such as dizziness, palpitations, or syncope.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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