hydroxychloroquine-sulfate and Cymbalta Interactions

Interactions between hydroxychloroquine-sulfate(hydroxychloroquine) and Cymbalta (duloxetine)

hydroxychloroquine and duloxetine (Moderate Drug-Drug)

MONITOR: Coadministration with drugs that are inhibitors of CYP450 2D6 may increase the plasma concentrations of duloxetine, which is partially metabolized by the isoenzyme. The interaction is expected to occur in patients who are CYP450 2D6 extensive metabolizers (approximately 93% of Caucasians and greater than 98% of Asians and individuals of African descent).

MANAGEMENT: The possibility of prolonged and/or increased pharmacologic effects of duloxetine should be considered during concomitant therapy with CYP450 2D6 inhibitors, particularly potent inhibitors such as quinidine, paroxetine, and fluoxetine.