hydroxychloroquine-sulfate and Codeine phosphate Interactions

Interactions between hydroxychloroquine-sulfate(hydroxychloroquine) and Codeine phosphate (codeine)

codeine and hydroxychloroquine (Moderate Drug-Drug)

MONITOR: Drugs that are inhibitors of CYP450 2D6 may interfere with the analgesic effect of codeine. The mechanism is decreased in vivo conversion of codeine to morphine, a metabolic reaction mediated by CYP450 2D6.

MANAGEMENT: The possibility of reduced or inadequate pain relief should be considered in patients receiving codeine with drugs that inhibit CYP450 2D6. An increase in the codeine dosage or a different analgesic agent may be necessary in patients requiring therapy with CYP450 2D6 inhibitors.