hydrochlorothiazide and Anzemet Interactions

Interactions between hydrochlorothiazide and Anzemet (dolasetron)

hydrochlorothiazide and dolasetron (Major Drug-Drug)

MONITOR CLOSELY: The risk of arrhythmia may be increased in patients taking dolasetron and diuretics. Dolasetron induced ECG changes (PR and QTc prolongation; QRS widening) have been observed in healthy volunteers and in controlled clinical trials. Diuretics may further predispose the patient to arrhythmia by inducing electrolyte abnormalities.

MANAGEMENT: Close clinical and laboratory monitoring for cardiac rhythm and electrolyte disturbances is recommended if this combination is used.