Drug interactions between hydrochlorothiazide/quinapril and Lyrica
| Results for the following 2 drugs: |
|---|
| hydrochlorothiazide/quinapril |
| Lyrica (pregabalin) |
Interactions between your selected drugs
quinapril ↔ pregabalin
Applies to:hydrochlorothiazide/quinapril and Lyrica (pregabalin)
MONITOR: Pregabalin has been associated with the development of angioedema, and coadministration with other drugs that are also known to cause angioedema (e.g., ACE inhibitors, angiotensin II receptor antagonists, renin inhibitors) may theoretically increase the risk. There have been postmarketing reports of angioedema in patients during initial and chronic treatment with pregabalin, some without a prior history of angioedema. Specific symptoms included swelling of the face, mouth (tongue, lips, and gums), and neck (throat and larynx). In some cases, the angioedema led to life-threatening respiratory compromise that required emergency treatment.
MANAGEMENT: Clinicians and patients should be aware of the potential for increased risk of angioedema when pregabalin is prescribed with other drugs that are also known to cause angioedema. Patients should be advised to promptly discontinue these medications and seek medical attention if they develop signs or symptoms suggestive of angioedema such as swelling of the face, extremities, eyes, lips, or tongue, and difficulty swallowing or breathing.
See also...
- Hydrochlorothiazide/quinapril Drug Interactions
- hydrochlorothiazide and quinapril General Consumer Information
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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