humulin-n and Adoxa tt Interactions

Interactions between humulin-n(insulin isophane) and Adoxa tt (doxycycline)

doxycycline and insulin isophane (Moderate Drug-Drug)

MONITOR: Tetracyclines may enhance the hypoglycemic effect of insulin by increasing tissue sensitivity to exogenous insulin.

MANAGEMENT: Blood glucose should be monitored closely whenever tetracyclines are prescribed to patients on insulin, especially if they are elderly or have renal impairment. The insulin dosage may require adjustment if an interaction is suspected. Patients should be apprised of the signs and symptoms of hypoglycemia (e.g., headache, dizziness, drowsiness, nausea, hunger, tremor, weakness, sweating, palpitations), how to treat it, and to contact their physician if it occurs.