Drug interactions between Humatin and Trexall
| Results for the following 2 drugs: |
|---|
| Humatin (paromomycin) |
| Trexall (methotrexate) |
Interactions between your selected drugs
methotrexate ↔ paromomycin
Applies to:Trexall (methotrexate) and Humatin (paromomycin)
MONITOR: Coadministration of an oral aminoglycoside and methotrexate may lead to decreased gastrointestinal absorption of methotrexate which could result in reduced efficacy of methotrexate. The proposed mechanism is a malabsorption syndrome caused by oral aminoglycosides. It has been suggested that increased absorption could occur with kanamycin.
MANAGEMENT: Patients should be closely monitored for altered efficacy and safety of methotrexate. Consider the intravenous route of administration for methotrexate to avoid the interaction.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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