granisetron-hydrochloride and Posaconazole Interactions

Interactions between granisetron-hydrochloride(granisetron) and Posaconazole (posaconazole)

granisetron and posaconazole (Moderate Drug-Drug)

MONITOR: Coadministration with posaconazole may significantly increase the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme. The mechanism is decreased clearance due to inhibition of CYP450 3A4 activity by posaconazole.

MANAGEMENT: Caution is advised if posaconazole must be used concomitantly with medications that undergo metabolism by CYP450 3A4, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever posaconazole is added to or withdrawn from therapy.