granisetron-hydrochloride and Luvox cr Interactions

Interactions between granisetron-hydrochloride(granisetron) and Luvox cr (fluvoxamine)

granisetron and fluvoxamine (Moderate Drug-Drug)

MONITOR: Coadministration with fluvoxamine may increase the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme. The mechanism is decreased clearance due to competitive inhibition of CYP450 3A4 activity by fluvoxamine.

MANAGEMENT: Caution is advised if fluvoxamine must be used concomitantly with medications that undergo metabolism by CYP450 3A4, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever fluvoxamine is added to or withdrawn from therapy.